Nucleobase analogs for degenerate hybridization devised through conformational pairing analysis
نویسندگان
چکیده
منابع مشابه
Nucleobase analogs for degenerate hybridization devised through conformational pairing analysis.
A conformational pairing analysis was used to devise nucleobase analogs capable of forming nonselective and energetically favorable base pairs opposite either the purine or the pyrimidine constituents of nucleic acids. 5-methylisocytosine and isoguanine were conceived as a degenerate pyrimidine and a degenerate purine, respectively. Data from previous DNA duplex melting experiments verified tha...
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ژورنال
عنوان ژورنال: BioTechniques
سال: 2007
ISSN: 0736-6205,1940-9818
DOI: 10.2144/000112602